This study aimed to compare the image quality and the quantitative DCE-MRI parameters using the k-space weighted image contrast reconstruction with variable-density golden angle stack-of-stars acquisition (4D-FB) to those of the conventional 3D-T1W turbo field echo sequence (e-THRIVE) in prostate cancer (PCa). Image quality assessment and the receiver operating characteristic curve (AUC) analysis of quantitative DCE-MRI parameters in discrimination PCa from normal tissue were performed. 4D-FB showed significantly higher SNR compared to e-THRIVE. No significant differences were observed in AUCs for each quantitative DCE-MRI parameter. 4D-FB may improve image quality of DCE-MRI with keeping effective pharmacokinetic information in PCa assessment.