We evaluated dynamic contrast enhanced MRI with a split injection protocol for diagnosis of prostate-cancer. We injected 30% of the standard dose, followed after two mins by 70% of the standard dose of gadoterat-meglumine. A signal intensity form of the standard Tofts model was used to extract physiological parameters. On average cancer had larger Ktrans and smaller ve than normal tissue obtained from both doses. Receiver operating characteristic analysis showed that area under curve was 0.776 for a combination of all parameters from the 30% and 70% doses. The split injection protocol combined with quantitative analysis may increase diagnostic accuracy.
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