Abstract #3908

Twofold Improved Tumor-to-Brain Contrast using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) Technique

Robert R Edelman^1,2, Nondas Leloudas³, Jianing Pang⁴, Julian Bailes⁵, Ryan Merrell⁶, and Ioannis Koktzoglou^3,7

¹Radiology, NorthShore University HealthSystem, EVANSTON, IL, United States, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Radiology, NorthShore University HealthSystem, Evanston, IL, United States, ⁴Siemens Medical Solutions USA, Chicago, IL, United States, ⁵Neurosurgery, NorthShore University HealthSystem, Evanston, IL, United States, ⁶Medicine, NorthShore University HealthSystem, Evanston, IL, United States, ⁷Pritzker School of Medicine, University of Chicago, Chicago, IL, United States

We describe a novel class of steady-state pulse sequence called T1 Relaxation-Enhanced Steady-State (T₁RESS). Several versions have been implemented including: (a) “bright blood” balanced T₁RESS (bT₁RESS), and (b) “dark blood” unbalanced T₁RESS (uT₁RESS). There is also a two-echo Dixon version for fat/water separation. In a brain tumor study, contrast-enhanced T₁RESS demonstrated a remarkable two-fold improvement in tumor-to-brain contrast as well as enhanced SNR compared with standard neuroimaging techniques, including MP-RAGE and T1 SPACE. Our initial results suggest that T₁RESS has great potential for oncological imaging in the brain, and with further development in other organ systems as well.

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