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Abstract #3907

Deep learning super-resolution MR spectroscopic imaging to map tumor metabolism in mutant IDH glioma patients

Xianqi Li1, Bernhard Strasser1, Kourosh Jafari-Khouzani2, Daniel P Cahill3, Jorg Dietrich4, Tracy T Batchelor4, Martin Bendszus5, Ulf Neuberger6, Philipp Vollmuth6, and Ovidiu Andronesi7
1Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2IBM Watson Health, Boston, MA, United States, 3Neurosurgery, Massachusetts General Hospital, Boston, MA, United States, 4Massachusetts General Hospital, Boston, MA, United States, 5Heidelberg University Hospital, Boston, MA, United States, 6Heidelberg University Hospital, Heidelberg, Germany, 7Massachusetts General Hospital,, Charlestown, MA, United States

We developed deep learning super-resolution MR spectroscopic imaging (MRSI) to map tumor metabolism in patients with mutant IDH glioma. A generative adversarial network (GAN) architecture comprised of a UNet neural network as the generator network and a discriminator network for adversarial training was employed to upsample MR spectroscopic imaging data with a factor of four. The preliminary results on simulated and in vivo data indicate that the proposed deep learning method is effective in enhancing the spatial resolution of metabolite maps which may better guide treatment in mutant IDH glioma patients.

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