The aim of this study was to detect the isocitrate dehydrogenase 1 (IDH 1) genotype in low grade gliomas using diffusion kurtosis imaging (DKI). The results indicated that IDH 1 wild-type gliomas have higher MK and lower MD values in tumor foci compared with mutant gliomas, and MK increased and MD decreased significantly in normal-appearing perilesional white matter (pWM) in all gliomas. Interestingly, lower FA in pWM than contralateral normal-appearing white matter was only seen in wild-type gliomas, while no difference was found in mutant-gliomas. These findings indicated that DKI were sensitive to differentiate IDH 1 genotypes in low-grade gliomas.
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