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Abstract #3920

Value of Diffusion Kurtosis Imaging in Detecting Isocitrate Dehydrogenase Genotype in Low-grade Gliomas

Tao Gong1, Liangjie Lin2, and Yihang Yang3
1Shandong Medical Imaging Research Institute, Jinan, China, 2Philips Healthcare, Beijing, China, 3Shandong provincal hospital, Jinan, China

The aim of this study was to detect the isocitrate dehydrogenase 1 (IDH 1) genotype in low grade gliomas using diffusion kurtosis imaging (DKI). The results indicated that IDH 1 wild-type gliomas have higher MK and lower MD values in tumor foci compared with mutant gliomas, and MK increased and MD decreased significantly in normal-appearing perilesional white matter (pWM) in all gliomas. Interestingly, lower FA in pWM than contralateral normal-appearing white matter was only seen in wild-type gliomas, while no difference was found in mutant-gliomas. These findings indicated that DKI were sensitive to differentiate IDH 1 genotypes in low-grade gliomas.

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