Abstract #3921

Simultaneously acquired PET and ASL imaging biomarkers are helpful in differentiating progression from pseudo-progression in treated gliomas

Nadya Pyatigorskaya^1,2,3, Arnaud Pellerin¹, Maya Kalife⁴, Marc Bertaux⁵, Marine Soret⁵, Didier Dormont¹, and Aurélie Kas⁵

¹Neuroradiology, Pitié-Salpêtrière Hospital, APHP, Sorbonne universite, Paris, France, ²UMR S 1127, CNRS UMR 722, ICM, Sorbonne Universités, Paris, France, ³CENIR, ICM, Sorbonne Universités, Paris, France, ⁴CENIR, ICM, Paris, France, ⁵Nuclear Medecine, Pitié-Salpêtrière Hospital, APHP, Sorbonne universite, Paris, France

We aimed at investigating the methods based on coupling cerebral perfusion (ASL) and amino-acid metabolism (18F-DOPA-PET) measurements to evaluate the diagnostic performance of simultaneous PET/MRI in glioma follow-up. Tumour isocontour maps of 18F-DOPA-PET and ASL T-maps were created using SPM and metabolic/perfusion abnormalities were evaluated with the asymmetry index z-score. SPM map analysis of significant-size clusters and semi-quantitative PET and ASL map evaluation were performed. The tumour isocontour maps and T-maps showed the highest specificity (100%) and sensitivity (94.1%) for ASL and 18F-DOPA analysis, allowing to achieve high diagnostic performance in differentiating between progression and pseudo-progression in treated gliomas.

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