Abstract #3923

High dual-contrast putamen MRI at 1.5T: Application to intraoperative MRI during neurosurgical procedure

Chan Hong Moon¹, Krystof Bankiewicz², Paul Larson², Adrian Kells³, Alastair J. Martin², Stephen Mancuso⁴, and Mark Richardson⁵

¹University of Pittsburgh, Pittsburgh, PA, United States, ²University of California San Francisco, San Francisco, CA, United States, ³Voyager Therapeutics Inc., Cambridge, MA, United States, ⁴UPMC, Pittsburgh, PA, United States, ⁵Massachusetts General Hospital, Boston, MA, United States

Neurosurgical planning/targeting/monitoring by MRI requires high contrast and excellent anatomical feature. Inversion recovery MRI, e.g., MPRAGE is known to be superior to T1w SPGR in making high contrast of WM vs. GM. However, it is not optimized for putamen/globus pallidus, i.e., important target nuclei in PD surgery, particularly iMRI scanner 1.5T (not 3T). In this study, we developed new dual-contrast MPRAGE and maximized T1 contrast in putamen as well as good anatomy of whole brain without additional acquisition compared to conventional MPRAGE. The proposed methods were applied to 1.5T iMRI during neurosurgical procedure of PD patients.

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