Abstract #3924

Detection of Cystathionine, 2-Hydroxyglutarate and Citrate in Oligodendrogliomas at 7T using Long-TE Semi-LASER

Uzay E Emir^1,2, Natalie E Voets³, Sarah E Larkin⁴, Nick De Pennington⁴, Puneet E Plaha⁴, Richard E Stacey⁴, James E Mccullagh⁴, Christopher J Schofield⁴, Stuart E Clare³, Peter Jezzard³, Thomas Cadoux-hudson⁴, and Olaf E Ansorge⁴

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³Wellcome Centre for Integrative Neuroimaging, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom

Given the rapid pace of discoveries in glioma genomics and metabolomics, it is likely that improvements in diagnostic imaging using UHF MRS can be made by systematically reanalyzing previously generated data in light of new knowledge. In this study, we tested this by reanalyzing existing UHF MRS spectra using a refined basis set that included the potential oncometabolite cystathionine

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