Chuanke Hou1, Guanzhong Gong1, Weiqiang Dou2, and Yong Yin1
1Department of Radiation Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China, 2GE Healthcare, MR Research China, Beijing, China
In this work, brain metastases (BM) were divided into multiple sub-volumes based on the cerebral blood flow (CBF) distribution derived by 3D arterial spin labeling (ASL) perfusion imaging. Due to the previously reported strong relationship, low CBF area was defined as the hypoxia area and selected as the region of interest (ROI). On this ROI, we further investigated the behaviors of conventional Intensity-modulated Radiotherapy (IMRT) plan, simultaneous integrated boost IMRT plan with and without constraints by increasing targeted doses, aiming to provide a new reference model for individualized radiotherapy for BM patients.