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Abstract #3964

Spatial localisation for mapping regional oxygen extraction fraction using parallel transmission saturation pulses at 7 T

Yan Tong1, Peter Jezzard1, Caitlin O'Brien1,2, and William T Clarke1
1Wellcome Centre for Integrative Neuroimaging, FMRIB Division, NDCN, University of Oxford, Oxford, United Kingdom, 2Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

T2‐relaxation under‐spin‐tagging (TRUST) is a robust spin tagging-based method to quantify oxygen extraction fraction (OEF), but it lacks spatial specificity. Recently, O’Brien et al. proposed a method at 3 T involving multiple saturation pulses to achieve spatial specificity. Parallel transmission (pTx) provides additional degrees of freedom for spatial localisation. A pTx RF pulse design strategy based on a shells trajectory was applied to perform regional OEF measurement at 7 T. Phantom experiments showed that repeating the RF pulses significantly improved the saturation efficiency.

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