Abstract #3966

High angular resolution susceptibility and diffusion imaging in post mortem chimpanzee brain: Tensor characteristics and similarities

Dimitrios G. Gkotsoulias¹, Riccardo Metere², Yanzhu Su¹, Cornelius Eichner¹, Torsten Schlumm¹, Roland Müller¹, Alfred Anwander¹, Toralf Mildner¹, Carsten Jäger¹, André Pampel¹, Catherine Crockford^3,4, Roman Wittig^3,4, Liran Samuni ^4,5, Kamilla Pleh ⁶, Chunlei Liu⁷, and Harald E. Möller¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, ³Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, ⁴Tai Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote D'ivoire, ⁵Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, United States, ⁶Project Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany, ⁷EECS, UC Berkeley, Berkeley, CA, United States

We present a ‘high angular resolution’ approach to susceptibility tensor imaging (STI) consisting of susceptibility-weighted acquisitions at 60 independent orientations in post- mortem chimpanzee brain. The derived susceptibility tensor and metrics are compared with the corresponding diffusion tensor-derived metrics and single-orientation quantitative susceptibility mapping (QSM) results. A preliminary approach to assess the voxel-wise relationship of the two tensors in white matter is presented: using machine learning strategies, an effort to estimate the susceptibility tensor from the diffusion tensor and minimum single-orientation QSM data in selected regions of interest was made.

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