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Abstract #3966

High angular resolution susceptibility and diffusion imaging in post mortem chimpanzee brain: Tensor characteristics and similarities

Dimitrios G. Gkotsoulias1, Riccardo Metere2, Yanzhu Su1, Cornelius Eichner1, Torsten Schlumm1, Roland Müller1, Alfred Anwander1, Toralf Mildner1, Carsten Jäger1, André Pampel1, Catherine Crockford3,4, Roman Wittig3,4, Liran Samuni 4,5, Kamilla Pleh 6, Chunlei Liu7, and Harald E. Möller1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, 3Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, 4Tai Chimpanzee Project, Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote D'ivoire, 5Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, United States, 6Project Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany, 7EECS, UC Berkeley, Berkeley, CA, United States

We present a ‘high angular resolution’ approach to susceptibility tensor imaging (STI) consisting of susceptibility-weighted acquisitions at 60 independent orientations in post- mortem chimpanzee brain. The derived susceptibility tensor and metrics are compared with the corresponding diffusion tensor-derived metrics and single-orientation quantitative susceptibility mapping (QSM) results. A preliminary approach to assess the voxel-wise relationship of the two tensors in white matter is presented: using machine learning strategies, an effort to estimate the susceptibility tensor from the diffusion tensor and minimum single-orientation QSM data in selected regions of interest was made.

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