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Abstract #3967

Rotation-Free Mapping of Magnetic Tissue Properties in White Matter

Anders Dyhr Sandgaard1, Valerij G. Kiselev2, Noam Shemesh3, and Sune Nørhøj Jespersen1,4
1Department of Clinical Medicine, Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, 2Medical Physics, Department of Radiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 3Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 4Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Mapping tissue magnetic properties may be a useful tool for understanding basic disease mechanism in neurodegenerative diseases. However, magnetic properties depend on the arrangement of magnetic susceptibility on all scales, including the microstructure, and typically require impractical sample rotations for robust estimation. By modeling white matter fibers as a system of cylinders, here we show that the first cumulant $$$\langle\Omega\rangle$$$ of the FID signal can be obtained without the need for sample rotation, by utilizing the fiber orientation distribution function estimated by diffusion imaging.

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