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Abstract #3968

Magnetic susceptibility source separation: validation with Monte-Carlo simulation & application to human brain with histological comparison

Hyeong-Geol Shin1, Young Hyun Yun2, Seong Ho Yoo2, Sehoon Jung3, Sunhye Kim3, Hyung Jin Choi 2, and Jongho Lee1
1Seoul National University, Seoul, Korea, Republic of, 2Seoul National University College of Medicine, Seoul, Korea, Republic of, 3Research Institute of Industrial Science and Technology, Pohang, Korea, Republic of

We validate the magnetic susceptibility source separation method, which is recently proposed to separate paramagnetic (e.g., iron) and diamagnetic sources (e.g., myelin), by performing Monte-Carlo simulation. Then, the method is applied to ex-vivo and in-vivo human brains and compared to histology. In the simulation, we show the method successfully estimates the paramagnetic and diamagnetic susceptibility concentrations. When compared to histology, the ex-vivo and in-vivo results demonstrated that the positive and negative susceptibility maps from the method highly correspond to the iron and myelin distributions, respectively, proving its feasibility as a tool to map iron and myelin distributions in the brain.

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