We validate the magnetic susceptibility source separation method, which is recently proposed to separate paramagnetic (e.g., iron) and diamagnetic sources (e.g., myelin), by performing Monte-Carlo simulation. Then, the method is applied to ex-vivo and in-vivo human brains and compared to histology. In the simulation, we show the method successfully estimates the paramagnetic and diamagnetic susceptibility concentrations. When compared to histology, the ex-vivo and in-vivo results demonstrated that the positive and negative susceptibility maps from the method highly correspond to the iron and myelin distributions, respectively, proving its feasibility as a tool to map iron and myelin distributions in the brain.
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