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Abstract #3987

Quantifying iron deposition in Multiple System Atrophy via multi-echo Quantitative Susceptibility Mapping

Marta Lancione1,2, Matteo Cencini2,3, Mauro Costagli3,4, Graziella Donatelli2,5, Michela Tosetti2,3, Claudio Pacchetti6, Pietro Cortelli7,8, and Mirco Cosottini5
1IMT School for Advanced Studies Lucca, Lucca, Italy, 2IMAGO7 Foundation, Pisa, Italy, 3IRCCS Stella Maris, Pisa, Italy, 4Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Sciences (DINOGMI), University of Genova, Genova, Italy, 5Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, 6Parkinson and Movement Disorder Unit, IRCCS Mondino Foundation, Pavia, Italy, 7Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, 8Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

In this work we quantified iron deposition in gray matter nuclei in a cohort of MSA patients with parkinsonian and cerebellar phenotypes using Quantitative Susceptibility Mapping (QSM). As it captures different tissues contribution depending on TE, we performed an ROI-based histogram analysis on susceptibility maps computed at each TE of a multi-echo GRE sequence. We observed significant differences among groups in several ROIs, such as putamen, globus pallidus, caudate nucleus, substantia nigra and dentate nucleus. The area under the ROC curve was higher for short TEs suggesting that short-TE QSM enhances diagnostic performances in the presence of strong susceptibility sources.

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