In this work we quantified iron deposition in gray matter nuclei in a cohort of MSA patients with parkinsonian and cerebellar phenotypes using Quantitative Susceptibility Mapping (QSM). As it captures different tissues contribution depending on TE, we performed an ROI-based histogram analysis on susceptibility maps computed at each TE of a multi-echo GRE sequence. We observed significant differences among groups in several ROIs, such as putamen, globus pallidus, caudate nucleus, substantia nigra and dentate nucleus. The area under the ROC curve was higher for short TEs suggesting that short-TE QSM enhances diagnostic performances in the presence of strong susceptibility sources.
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