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Abstract #3988

Clinical correlations of iron-rich deep grey matter of MS patients

Ibrahim Khormi1,2, Oun Al-iedani1,2, Amir Fazlollahi2,3, Bryan Paton2,4, Jeannette Lechner-Scott2,4,5, Abdulaziz Alshehri1,2, Kieran O'Brien6,7, Steffen Bollmann8, Rishma Vidyasagar9, Scott Ayton9, Anne-Louise Ponsonby9,10, and Saadallah Ramadan1,2
1School of Health Sciences, University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3CSIRO Health and Biosecurity, Brisbane, Australia, 4University of Newcastle, Newcastle, Australia, 5John Hunter Hospital, Newcastle, Australia, 6Siemens Healthcare Pty Ltd, Brisbane, Austria, 7ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia, 8The University of Queensland, Brisbane, Australia, 9The Florey Institute of Neuroscience & Mental Health, Parkville, Australia, 10Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia

This novel study compared quantitative magnetic susceptibility signal of deep grey matter (DGM) structures in the MS brain. We evaluated the QSM metrics in selected deep grey matter regions in 5 RRMS patients and 9 matched HCs. The STI suite software package was used for QSM image reconstruction. Compared to a reference region in HCs, a significant susceptibility change was detected in most DGM regions showing statistically significant RRMS cohort differences. QSM metrics in caudate showed strong correlations with depression scores, while pallidum and thalamus correlated significantly with anxiety. While results are limited due to small numbers, they provide the opportunity for further investigation in larger cohorts and strengthen these preliminary results.

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