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Abstract #3991

Quantitative Susceptibility Mapping of Venous Vessels in Neonates With Perinatal Asphyxia

Alexander Mark Weber1, Yuting Zhang2, Christian Kames3, and Alexander Rauscher1
1Pediatrics, UBC, Vancouver, BC, Canada, 2Radiology, Children’s Hospital of Chongqing Medical University, Chongqing, China, 3Physics, UBC, Vancouver, BC, Canada

We aimed to test whether Cerebral venous oxygen saturation (CSVO2) could be measured using quantitative susceptibility mapping (QSM) in three distinct groups: healthy term neonates, and asphyxia injured term and preterm neonates.

We acquired multi-echo gradient echo MRI data in 16 neonates with perinatal asphyxia and moderate or severe hypoxic-ischemic encephalopathy (HIE) (eight term-age, eight preterm, in eight healthy term-age controls.

QSM derived oxygen saturation values in preterm and term neonates agreed well with past literature. CSVO2 in preterm and term neonates with HIE, however, were not found to be significantly different from each other or healthy controls.

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