Abstract #3992

Investigating the Effect of Positive Airways Pressure on Venous Oxygenation in Sickle Cell Anemia with Quantitative Susceptibility Mapping

Russell Murdoch¹, Hanne Stotesbury², Jamie Kawadler², Dawn Saunders², Fenella Kirkham², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

In 88 sickle cell anaemia (SCA) patients and 30 healthy controls, quantitative susceptibility mapping (QSM) showed significantly lower venous oxygen saturation (Y_v) in the superior sagittal sinus of SCA patients. SCA subjects with silent cerebral infarcts (SCI) showed significantly lower Y_v relative to those without SCI. 39 SCA subjects participated in a clinical study investigating the effect of auto-adjusting positive airways pressure (APAP) over a period of six months. No significant Y_v differences were observed between 21 patients receiving APAP and 18 receiving standard care. In the APAP group, treatment compliance was positively correlated with increases in Y_v.

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