Brain oxygenation can be measured using either T2-based methods or magnetic susceptibility-based methods. This study validates QSM and CISSCO methods in measuring the oxygenation in the internal cerebral vein and compares the results in sickle cell disease patients, anemia subjects with normal hemoglobin and healthy controls. Both methods reveal the group difference in the oxygen saturation in the deep structures. The limitations for both methods are discussed and the explanation for the bias between the two methods is provided.
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