Little is known about the histopathology of silent cerebral infarcts (SCI) in sickle cell anaemia (SCA). Therefore, we measured the magnetic susceptibility (χ) of SCI in 45 SCA subjects and 10 healthy controls using quantitative susceptibility mapping (QSM) calculated from two different gradient-echo (GRE) acquisitions. Significantly lower χ was measured in lesions located in the parietal lobes relative to the frontal lobe. No significant relationships with mean lesion χ were observed with subject age, lesion size or depth in white matter. Strong correlations and minimal biases were observed between mean lesion χ measured using the two GRE acquisitions.