Abstract #3994

Investigating the Magnetic Susceptibility of Silent Cerebral Infarcts in Sickle Cell Anaemia Using Two Different Gradient Echo Acquisitions

Russell Murdoch¹, Hanne Stotesbury², Jamie Kawadler², Dawn Saunders², Fenella Kirkham², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Little is known about the histopathology of silent cerebral infarcts (SCI) in sickle cell anaemia (SCA). Therefore, we measured the magnetic susceptibility (χ) of SCI in 45 SCA subjects and 10 healthy controls using quantitative susceptibility mapping (QSM) calculated from two different gradient-echo (GRE) acquisitions. Significantly lower χ was measured in lesions located in the parietal lobes relative to the frontal lobe. No significant relationships with mean lesion χ were observed with subject age, lesion size or depth in white matter. Strong correlations and minimal biases were observed between mean lesion χ measured using the two GRE acquisitions.

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