We explored the link between iron accumulation and neuroinflammation in basal ganglia in SLE using quantitative susceptibility mapping. We hypothesized that SLE patients, and in particular NPSLE patients would have increased numbers of activated microglia co-localizing with iron, which in turn would be reflected in increased local susceptibility. Based on QSM results in patients, as well as on iron staining of post-mortem SLE brain tissue, our results suggest that neuroinflammation in NPSLE is not necessarily associated with iron accumulation, and that the inflammatory pathomechanism in SLE may differ from the one observed in neurodegenerative diseases and in multiple sclerosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords