Abstract #4000

Scan Efficiency Optimisation for Quantitative Susceptibility Mapping of White Matter at 7T.

Jan Sedlacik^1,2, Raphael Tomi-Tricot^1,3, Pip Bridgen^1,2, Tom Wilkinson^1,2, Sharon Giles^1,2, Karin Shmueli⁴, Jo V Hajnal^1,2, and Shaihan J Malik^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King’s College London, London, United Kingdom, ²Biomedical Engineering Department, School of Biomedical Engineering & Imaging Sciences, King’s College London, London, United Kingdom, ³MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, ⁴MRI Group, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

Quantitative Susceptibility Mapping (QSM) used for microstructural assessment of white matter (WM) is very attractive at ultra high magnetic field strengths, due to the increased signal-to-noise ratio (SNR) and phase sensitivity. This allows shortening echo and repetition times and, therefore, acquisition time. Further advantages of QSM are the low flip angles used for scanning, which results in low specific absorption rates, and the B₁ insensitivity of the signal phase. However, suboptimal choice of imaging parameters will result in suboptimal SNR. The purpose of this work is to find and test optimal scanning parameters for QSM of the WM at 7T.

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