Priya S Balasubramanian1,2, Alexandra Grace Roberts1,2, Pascal Spincemaille2, Thanh Nguyen 2, and Yi Wang1,2
1Cornell University, New York City, NY, United States, 2Weill Cornell Medical College, New York City, NY, United States
QSM uses a mask to separate tissue of interest from background to avoid the strong susceptibility sources and poor signals that are known to cause artifacts in QSM. In brain QSM, the strongly paramagnetic superior sagittal sinus (SSS) lies at the border of brain mask. Perturbing the brain mask by reducing the SSS inclusion in QSM reconstruction also affects the convergence of strong susceptibility sources inside the brain. This mask perturbation propagates into QSM perturbation, which may be used as a measure of artifacts associated with strong susceptibility sources as validated in numerical phantom and COSMOS data.