Abstract #4016

MR SIGnature MAtching (MRSIGMA) with retrospective self-validation for real-time volumetric tumor motion imaging

Nathanael Kim¹, Kathryn Tringale², Christopher Crane², Neelam Tyagi¹, and Ricardo Otazo^1,3

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

MRSIGMA is a promising real-time volumetric imaging for MRI-guided adaptive radiotherapy using a MR-Linac system. However, the lack of a real-time 3D reference image acquired with similar temporal resolution introduces significant challenges for in vivo validation. This work proposes a retrospective self-validation for MRSIGMA, where the same data used for real-time imaging are used to create a non-real-time reference. MRSIGMA with self-validation is tested in patients with liver tumors using quantitative metrics defined on the tumor and nearby organs-at-risk structures.

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