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Abstract #4021

UTE-MRI complements CT in bone characterization for improved proton therapy dose calculation

Xin Miao1, Raanan Marants2, Thomas Benkert3, Evangelia Kaza2, Jeremy Bredfeldt2, and Atchar Sudhyadhom2
1Siemens Medical Solutions USA Inc., Boston, MA, United States, 2Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany

CT-based proton therapy dose calculation suffers from significant uncertainties that critically limit clinical efficacy. Previous works demonstrated improved proton range calculation by combining quantitative MRI with CT. This study extends those works into bone, a challenging region for tissue characterization. CT and a novel UTE MRI technique were used to investigate their complimentary information for bone characterization. Both phantom and in vivo experiments showed that combining UTE-MRI and CT measurements achieved accurate classification of bone types. Understanding of bone types can have significant implications on the determination of bone tissue composition and, ultimately, accuracy of radiation delivery in proton therapy.

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