Desmoid tumors are challenging to control with chemotherapy, surgery, or radiation. This retrospective review evaluated patients with extra-abdominal desmoid tumors treated with MR-guided cryoablation at our institution over two years. The primary endpoint was tumor volume change before and 3 months after cryoablation; the secondary endpoint was the change in health status assessed at the same interval. Our study demonstrates MR-guided cryoablation results in the reduction of both tumor size and improvement in health status scores. No severe adverse events occurred. We conclude that MR-guided cryoablation is an effective and safe treatment option for desmoid tumors.