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Abstract #4023

PET/MRI Assessment of 90Yttrium Prostate Localization and Acute Response Following Intra-arterial Radioembolization in A Canine Model

Weiguo Li1,2, Kathleen Harris1, Amrutha Mylarapu1, Malcolm Burks1, Simone Raiter1, Vanessa Louise Gates1, Andrew Gordon1, Robert Lewandowski1, Riad Salem1, and Samdeep Mouli1
1Radiology, Northwestern University, Chicago, IL, United States, 2Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Local-regional therapy of prostate cancer with 90Yttrium (90Y) radioembolization is a novel radiotherapy approach that delivers high-dose radiation therapy with minimal non-target radiation. However, currently no accurate way exists to evaluate radiation effects noninvasively following embolization. In this study, we sought to apply PET/MRI to assess biodistribution of 90Y and estimate effects of treatment following 90Y prostate artery radioembolization in a dog prostate model.

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