Abstract #4023

PET/MRI Assessment of 90Yttrium Prostate Localization and Acute Response Following Intra-arterial Radioembolization in A Canine Model

Weiguo Li^1,2, Kathleen Harris¹, Amrutha Mylarapu¹, Malcolm Burks¹, Simone Raiter¹, Vanessa Louise Gates¹, Andrew Gordon¹, Robert Lewandowski¹, Riad Salem¹, and Samdeep Mouli¹

¹Radiology, Northwestern University, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Local-regional therapy of prostate cancer with ⁹⁰Yttrium (⁹⁰Y) radioembolization is a novel radiotherapy approach that delivers high-dose radiation therapy with minimal non-target radiation. However, currently no accurate way exists to evaluate radiation effects noninvasively following embolization. In this study, we sought to apply PET/MRI to assess biodistribution of ⁹⁰Y and estimate effects of treatment following ⁹⁰Y prostate artery radioembolization in a dog prostate model.

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