Abstract #4032

In vivo hypoxia monitoring using a novel single sided NMR device

Dion G Thomas¹, Freya G Harrison², Paul D Teal³, Petrik Galvosas^1,4, Mary J Berry^2,5, Sergei Obruchkov⁶, and Yu-Chieh Tzeng²

¹School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand, ²Centre for Translational Physiology, University of Otago, Wellington, New Zealand, ³School of Engineering and Computer Science, Victoria University of Wellington, Wellington, New Zealand, ⁴MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington, New Zealand, ⁵Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand, ⁶Robinson Research Institute, Victoria University of Wellington, Wellington, New Zealand

In this study, we investigate how a low field single-sided NMR device can be used to monitor brain tissue properties in-vivo. This device produces a B₀ field with a sweet spot in the brain, which defines the region of tissue that is measured. An ovine model of brain hypoxia was developed, to allow tissue oxygenation to be controlled. We observed that the T₂ decreased during hypoxia, recovering once normal oxygenation levels were re-established. These results shows that single-sided NMR devices have the potential to be used for real-time monitoring applications.

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