Abstract #4071

Impact of sustained Synovitis on Knee Joint Structural Degeneration: 4-Year MRI Data from the Osteoarthritis Initiative

Sara Ramezanpour¹, Thanat Kanthawang ^1,2, John Lynch ³, Thomas M Link ¹, and Gabby B Joseph¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand, Chiang Mai, Thailand, ³Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States

Synovial inflammation is a well-known risk factor of osteoarthritis (OA). Several semi-quantitative scores have been developed to grade synovitis using non-contrast enhanced MRI studies of the knee. However, the role of inflammatory processes in the progression of knee OA is yet to be fully understood. One hundred and eighty individuals with right knee MRIs at baseline, 2 and 4 years were studied using MRI-based semi-quantitative synovitis scores measuring presence/absence as well as severity of synovitis Subjects with sustained synovitis had greater progression of meniscus, bone marrow and cartilage abnormalities compared to controls without sustained synovitis.

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