Abstract #4072

AcidoCEST MRI pH is strongly correlated with GLUT1 immunohistochemistry in multiple myeloma

Alecio Lombardi^1,2, Jonathan Wong^1,2, Rachel High^1,2, Ya-Jun Ma², Adam Searleman², Saeed Jerban², Qingbo Tang^1,2, Jiang Du^1,2, Patrick Frost^3,4, and Eric Y. Chang^1,2

¹Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, ²Radiology, University of California, San Diego, CA, United States, ³Greater Los Angeles Veteran Administration Healthcare System, Los Angeles, CA, United States, ⁴University of California, Los Angeles, CA, United States

Multiple myeloma (MM) is a malignant plasma cell disease. Adaptive responses to hypoxia may be an essential element in its progression. The purpose of this study was to determine the feasibility of acidoCEST MRI for pHe measurement on a mouse model of MM with comparison with GLUT1 staining.

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