Abstract #4085

Directional and Inter-acquisition Variability in DWI (DAVID)

Jay M. Pittman^1,2, Aritrick Chatterjee^1,2, Teodora Szasz³, Grace Lee^1,2, Mihai Giurcanu⁴, Milica Medved^1,2, Ambereen Yousuf^1,2, Ajit Devaraj⁵, Aytekin Oto^1,2, and Gregory S. Karczmar^1,2

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, The University of Chicago, Chicago, IL, United States, ³Research Computing Center, The University of Chicago, Chicago, IL, United States, ⁴Department of Public Health Sciences, The University of Chicago, Chicago, IL, United States, ⁵Philips Research North America, Cambridge, MA, United States

Diffusion Weighted Imaging (DWI) MRI detects prostate cancers but is very sensitive to motion artifacts. There has been little quantitative evaluation of variability to guide clinical use of DWI. We found very high variability between individual acquisitions used for averaging at high b-values (% ranges of 74.08% - 115.56% in cancers and 53.53% - 159.91% in normal prostate tissue), primarily due to motion during diffusion-sensitizing gradients. High signals in cancer voxels appear in some acquisitions but not others. Therefore, standard averaging can obscure cancers. We propose alternative methods for combining information from individual images at each b-value to maximize diagnostic accuracy.

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