The dependence of apparent diffusion coefficient (ADC) on echo time (TE) has been observed in a number of biological tissues. Such coupling can be exploited to extract tissue microstructural information. We herein introduce a time-efficient sequence that is capable of studying the interplay between ADC and TE. The sequence incorporated multiple echo-train readouts into diffusion-weighted echo planar imaging, together with a 2D RF excitation pulse to reduce the FOV, thereby allowing multiple effective TEs in an acquisition. With this sequence, ADCs were evaluated at three TEs and T2*s at three b-values. The proposed technique has been demonstrated in the prostate.
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