Abstract #4093

Characterization of prostate cancer and benign prostatic hyperplasia using IVIM-DKI with parameter-reconstruction method

Archana Vadiraj Malagi¹, Virender Kumar², Kedar Khare³, Chandan J. Das⁴, and Amit Mehndiratta^1,5

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Nuclear Magnetic Resonance (NMR),, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ⁵Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

IVIM-DKI was used to evaluate clinical utility and diagnostic performance of IVIM-DKI parameters in characterization of prostate cancer(PCa) against benign prostatic hyperplasia(BPH) and healthy tissues. Sixteen patients suffering from PCa and BPH were recruited and underwent IVIM-DKI with routine MR sequences and biopsy. IVIM-DKI signal was modelled using hybrid model with total variation (TV) penalty function which removes any spurious values in parameters adaptively. HY with TV method produced high diagnostic performance (AUC:D=0.94-0.98, f=0.82-0.85 and k=0.85-0.91) than HY method for all tissues and high-quality parameter maps. IVIM-DKI parameters (D,f,k) showed significant differences between tumor and BPH and healthy tissue.

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