Abstract #4097

Non-Invasive Prostate Metabolic and Cytometric Imaging: Insights from Activity MRI [aMRI]

Xin Li¹, Eric M. Baker¹, Brendan Moloney¹, Ryan P. Kopp², Fergus V. Coakley³, Mark G. Garzotto⁴, and Charles S. Springer¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Urology, Oregon Health & Science University, Portland, OR, United States, ³Radiology, Oregon Health & Science University, Portland, OR, United States, ⁴Urology, Portland VA Center, Portland, OR, United States

The first aMRI [activity MRI] parametric maps of malignant prostate are presented. They show the differences in cell density [r (cells/μL)], average cell volume [V (pL)], and on-going metabolic activity across the prostate. Metabolic activity is represented by the mean steady-state cellular water efflux rate constant [k_io (s^-1)], which reflects homeostatic cytolemmal Na⁺,K⁺-ATPase [NKA] enzymatic turnover [fmol(ATP)consumed/s/cell]. In a known Gleason (3 + 4) tumor, r is increased, while V and k_io are decreased – relative to normal-appearing tissue. Such changes are sensible, and these new biomarkers may be diagnostic and/or predictive.

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