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Abstract #4096

Application of High Spectral and Spatial resolution (HiSS) MRI in prostate: a pilot study

Milica Medved1,2, Aritrick Chatterjee1,2, Ajit Devaraj3, Carla Harmath1, Grace Lee1, Ambereen Yousuf1,2, Tatjana Antic4, Aytekin Oto1,2, and Gregory S Karczmar1,2
1Radiology, The University of Chicago, Chicago, IL, United States, 2Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, The University of Chicago, Chicago, IL, United States, 3Philips Research NA, Cambridge, MA, United States, 4Pathology, The University of Chicago, Chicago, IL, United States

HiSS MRI is an echo-planar spectroscopic imaging (EPSI)-based method focusing on the shape and structure of the water and fat resonances. In the prostate, temporal signal decay parameters (ROC AUC 0.74-0.91) and spectral resonance shape parameters (ROC AUC 0.83-0.91) show high diagnostic potential. Spectral shape parameters do not correlate strongly with temporal decay parameters. Thus, they carry information complementary to the standard clinical multi-parametric MRI and can likely be utilized to improve its diagnostic performance in prostate cancer.

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