HiSS MRI is an echo-planar spectroscopic imaging (EPSI)-based method focusing on the shape and structure of the water and fat resonances. In the prostate, temporal signal decay parameters (ROC AUC 0.74-0.91) and spectral resonance shape parameters (ROC AUC 0.83-0.91) show high diagnostic potential. Spectral shape parameters do not correlate strongly with temporal decay parameters. Thus, they carry information complementary to the standard clinical multi-parametric MRI and can likely be utilized to improve its diagnostic performance in prostate cancer.
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