Abstract #4096

Application of High Spectral and Spatial resolution (HiSS) MRI in prostate: a pilot study

Milica Medved^1,2, Aritrick Chatterjee^1,2, Ajit Devaraj³, Carla Harmath¹, Grace Lee¹, Ambereen Yousuf^1,2, Tatjana Antic⁴, Aytekin Oto^1,2, and Gregory S Karczmar^1,2

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, The University of Chicago, Chicago, IL, United States, ³Philips Research NA, Cambridge, MA, United States, ⁴Pathology, The University of Chicago, Chicago, IL, United States

HiSS MRI is an echo-planar spectroscopic imaging (EPSI)-based method focusing on the shape and structure of the water and fat resonances. In the prostate, temporal signal decay parameters (ROC AUC 0.74-0.91) and spectral resonance shape parameters (ROC AUC 0.83-0.91) show high diagnostic potential. Spectral shape parameters do not correlate strongly with temporal decay parameters. Thus, they carry information complementary to the standard clinical multi-parametric MRI and can likely be utilized to improve its diagnostic performance in prostate cancer.

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