Abstract #4129

Relationship between MRI-derived lesion metrics and clinical characteristics in patients with Familial Cerebral Cavernous Malformations

Sivakami Avadiappan¹, Jeffrey Nelson², Marc Mabray³, Blaine Hart³, Leslie Morrison⁴, Atif Zafar⁴, Michel Torbey⁴, Helen Kim^2,5, and Janine Lupo¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, United States, ³Department of Radiology, University of New Mexico, Albuquerque, NM, United States, ⁴Department of Neurology, University of New Mexico, Albuquerque, NM, United States, ⁵Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States

Cerebral cavernous malformations (CCMs) are vascular lesions composed of abnormally enlarged small blood vessels and are characterized by symptoms such as seizures and hemorrhages. In this study, we explore the relationship between serial MR imaging metrics and clinical markers of CCM disease severity. A semi-automated algorithm was applied on 57 patients to segment lesions. Age was associated with lesion count and obesity was inversely related to the lesion count. The lesion burdens in brainstem and temporal lobe were related to hemorrhagic and seizure events. These imaging metrics can function as surrogate markers for risk stratification in these patients.

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