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Abstract #4150

Cerebrovascular dual-venc 4D flow MRI: Assessment of arterial pulsatility and resistance measures in intracranial atherosclerotic disease

Jackson Moore1, Maria Aristova1, Ramez Abdalla1, Ann Ragin1, Eric Russell1, Fan Caprio2, Michael Hurley1, Susanne Schnell3, Sameer A. Ansari1, and Michael Markl1
1Radiology, Northwestern University, Chicago, IL, United States, 2Neurology, Northwestern University, Chicago, IL, United States, 3Universitaet Greifswald, Greifswald, Germany

Intracranial atherosclerotic disease (ICAD) is a known risk factor for ischemic stroke. There is a need to develop quantitative imaging biomarkers to identify patients who may not respond to medical management. Here, the pulsatility index (PI) and resistivity index (RI) are derived from 4D flow MRI using a semi-automated vessel identification and segmentation workflow for 7 subjects with severe ICAD. Initial results show significant asymmetries (PI: 0.89 ± 0.2 vs 1.06 ± 0.1, p = 0.04; RI: 0.92 ± 0.1 vs 1.03 ± 0.07, p = 0.009) for affected vessels as well as contralateral hemisphere changes compared to controls.

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