Distal intracranial artery length measurement on TOF-MRA is a biomarker of age-related vascular changes but its measurement reproducibility in multi-center setting is unknown. We studied the dependence of measurement reproducibility on protocol and scanner platform variation. Reproducibility increased with increasing superior-inferior TOF-MRA coverage and consistency of imaging parameters. After correcting for these factors, high reproducibility was achieved between Philips 3T and Siemens 3T scanner platforms suggesting feasibility of quantitative intracranial vessel length measurements for multi-platform serial MRI studies.
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