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Abstract #4174

Quantifying lactate using double quantum filtered 1H MRS with adiabatic refocusing pulses at 7 T

Fabian Niess1, Albrecht Ingo Schmid1, Graham Kemp2, Ewald Moser1, Maxim Zaitsev1, and Martin Meyerspeer1
1High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria, 2Department of Musculoskeletal & Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom

The purpose of this study was to develop a novel single-shot acquisition scheme to quantify the lactate doublet at 1.3 ppm in skeletal muscle at ultrahigh field of 7 T. A double quantum filtered 1H MRS sequence was implemented using a Shinnar-Le-Roux optimised 90° pulse and adiabatic full-passage 180° pulses for slice-selective excitation and refocusing, respectively. The lactate resonance was successfully quantified in phantom (free lactate in solution) and ex vivo measurements (lactate injected into a meat specimen). Muscle fibre orientation and corresponding effects on the observed lactate resonance were in good agreement with the literature.

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