Abstract #4174

Quantifying lactate using double quantum filtered 1H MRS with adiabatic refocusing pulses at 7 T

Fabian Niess¹, Albrecht Ingo Schmid¹, Graham Kemp², Ewald Moser¹, Maxim Zaitsev¹, and Martin Meyerspeer¹

¹High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria, ²Department of Musculoskeletal & Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom

The purpose of this study was to develop a novel single-shot acquisition scheme to quantify the lactate doublet at 1.3 ppm in skeletal muscle at ultrahigh field of 7 T. A double quantum filtered ¹H MRS sequence was implemented using a Shinnar-Le-Roux optimised 90° pulse and adiabatic full-passage 180° pulses for slice-selective excitation and refocusing, respectively. The lactate resonance was successfully quantified in phantom (free lactate in solution) and ex vivo measurements (lactate injected into a meat specimen). Muscle fibre orientation and corresponding effects on the observed lactate resonance were in good agreement with the literature.

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