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Abstract #4180

A Short TR Adiabatic Inversion Recovery Zero Echo Time (STAIR-ZTE) Sequence with Interleaved Encoding and a Modulated RF Pulse for Myelin Imaging

Hyungseok Jang1, Yajun Ma1, Michael Carl2, Saeed Jerban1, Roland Lee1, Eric Y Chang1,3, Jody Corey-Bloom1, and Jiang Du1
1University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

It is challenging to directly image myelin due to its extremely short T2* (<300µs at 3T). Adiabatic Inversion Recovery prepared Ultrashort Echo Time (IR-UTE) imaging has been proposed for direct myelin imaging in human brain. More recently, Short Repetition Time Adiabatic Inversion Recovery (STAIR) has been proposed as a novel contrast mechanism for myelin imaging with improved suppression of long T2 signal. In this study, we explored feasibility of STAIR based Zero Echo Time (STAIR-ZTE) combined with an amplitude- and phase-modulated RF pulse and interleaved Water- and Fat-Suppressed Proton Projection MRI (WASPI) for myelin imaging in human brain.

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