Abstract #4180

A Short TR Adiabatic Inversion Recovery Zero Echo Time (STAIR-ZTE) Sequence with Interleaved Encoding and a Modulated RF Pulse for Myelin Imaging

Hyungseok Jang¹, Yajun Ma¹, Michael Carl², Saeed Jerban¹, Roland Lee¹, Eric Y Chang^1,3, Jody Corey-Bloom¹, and Jiang Du¹

¹University of California, San Diego, San Diego, CA, United States, ²GE Healthcare, San Diego, CA, United States, ³Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

It is challenging to directly image myelin due to its extremely short T₂* (<300µs at 3T). Adiabatic Inversion Recovery prepared Ultrashort Echo Time (IR-UTE) imaging has been proposed for direct myelin imaging in human brain. More recently, Short Repetition Time Adiabatic Inversion Recovery (STAIR) has been proposed as a novel contrast mechanism for myelin imaging with improved suppression of long T₂ signal. In this study, we explored feasibility of STAIR based Zero Echo Time (STAIR-ZTE) combined with an amplitude- and phase-modulated RF pulse and interleaved Water- and Fat-Suppressed Proton Projection MRI (WASPI) for myelin imaging in human brain.

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