Abstract #4179

Optimization of Magnetization Transfer Contrast for EPI FLAIR Brain Imaging

Serdest Demir¹, Bryan Clifford², Thorsten Feiweier³, Tom Hilbert⁴, Zahra Hosseini⁵, Augusto Lio Goncalves Filho¹, Azadeh Tabari¹, Wei-Ching Lo², Maria Gabriela Figueiro Longo¹, Michael Lev¹, Pamela Schaefer¹, Otto Rapalino¹, Kawin Setsompop⁶, Berkin Bilgic⁶, Stephen Cauley⁶, Susie Huang¹, and John Conklin¹

¹Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Siemens Medical Solutions, Boston, MA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Siemens Healthcare AG, Lausanne, Switzerland, ⁵Siemens Medical Solutions, Atlanta, GA, United States, ⁶Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

EPI FLAIR images have lower tissue contrast than conventional TSE images due to the absence of significant magnetization transfer (MT) effects, which limits their acceptability to radiologists and clinicians. In this study, we developed an MT-prepared EPI FLAIR acquisition, and determined the optimal parameters of the MT-preparation module to match the tissue contrast of clinical reference TSE FLAIR images. This approach may facilitate clinical adoption of EPI FLAIR images for a variety of applications, including those where ultrafast imaging is desired (e.g., acute stroke, motion prone patients, pediatrics).

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