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Abstract #4179

Optimization of Magnetization Transfer Contrast for EPI FLAIR Brain Imaging

Serdest Demir1, Bryan Clifford2, Thorsten Feiweier3, Tom Hilbert4, Zahra Hosseini5, Augusto Lio Goncalves Filho1, Azadeh Tabari1, Wei-Ching Lo2, Maria Gabriela Figueiro Longo1, Michael Lev1, Pamela Schaefer1, Otto Rapalino1, Kawin Setsompop6, Berkin Bilgic6, Stephen Cauley6, Susie Huang1, and John Conklin1
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Siemens Medical Solutions, Boston, MA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Siemens Healthcare AG, Lausanne, Switzerland, 5Siemens Medical Solutions, Atlanta, GA, United States, 6Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

EPI FLAIR images have lower tissue contrast than conventional TSE images due to the absence of significant magnetization transfer (MT) effects, which limits their acceptability to radiologists and clinicians. In this study, we developed an MT-prepared EPI FLAIR acquisition, and determined the optimal parameters of the MT-preparation module to match the tissue contrast of clinical reference TSE FLAIR images. This approach may facilitate clinical adoption of EPI FLAIR images for a variety of applications, including those where ultrafast imaging is desired (e.g., acute stroke, motion prone patients, pediatrics).

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