Abstract #4208

A Combined Solid-State 1H and 31P Magnetic Resonance Imaging to Assess Bone Mineral and Matrix Densities in Rat bones

Victor Babu Kassey^1,2,3,4, Matthias Walle¹, Jonathan Egan¹, Diana Yeritsyan¹, Yaotang Wu^2,3,4, Brian D Snyder^2,4, Edward Rodriguez^1,2, Jerome Ackerman^2,5, and Ara Nazarian^1,2,4

¹Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA, United States, ⁵Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Bone matrix and mineral densities (BMD) are important parameters to identify bone diseases such as osteoporosis and osteomalacia. Micro-CT, CT, and DXA scans provide bone mineral densities but not bone matrix. In this study, a non-invasive, radiation-free, and clinically proven combined 1H/31P MRI method was developed to measure bone matrix and mineral densities from rat bones from the same volume-of-interest sequentially in a single session. A custom-designed home-made double-tuned single volume coil was designed for 7T, and 1H/31P ZTE rat bone images were obtained, auto-registered, bone matrix and mineral densities were computed quantitatively, and osteoporosis and osteomalacia were successfully identified.

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