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Abstract #4208

A Combined Solid-State 1H and 31P Magnetic Resonance Imaging to Assess Bone Mineral and Matrix Densities in Rat bones

Victor Babu Kassey1,2,3,4, Matthias Walle1, Jonathan Egan1, Diana Yeritsyan1, Yaotang Wu2,3,4, Brian D Snyder2,4, Edward Rodriguez1,2, Jerome Ackerman2,5, and Ara Nazarian1,2,4
1Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA, United States, 5Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Bone matrix and mineral densities (BMD) are important parameters to identify bone diseases such as osteoporosis and osteomalacia. Micro-CT, CT, and DXA scans provide bone mineral densities but not bone matrix. In this study, a non-invasive, radiation-free, and clinically proven combined 1H/31P MRI method was developed to measure bone matrix and mineral densities from rat bones from the same volume-of-interest sequentially in a single session. A custom-designed home-made double-tuned single volume coil was designed for 7T, and 1H/31P ZTE rat bone images were obtained, auto-registered, bone matrix and mineral densities were computed quantitatively, and osteoporosis and osteomalacia were successfully identified.

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