Abstract #4216

Quantitative Magnetization Transfer MRI of the Knee Meniscus: Correlations with Biochemistry and Histology

Kirstin D Olsen¹, Lumeng Cui¹, Brennan E Berryman², Ives R Levesque³, and Emily J McWalter²

¹Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ²Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ³Medical Physics, McGill University, Montreal, QC, Canada

The objective of this research was to determine if quantitative magnetization transfer (qMT) MRI can assess knee meniscus tissue health. Cadaver knee menisci underwent qMT assessment, biochemical content assessment, and histological scoring. Weak correlations were found between T_1f and collagen content, T_1f and histology score, and the histology scores and T_2f and T_2b. A moderate correlation was found between T_2fand collagen content. qMT shows promise as a measure of meniscal tissue health but future studies with more severely damaged tissue are required to elucidate relationships between qMT and measures of meniscal content and health.

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