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Abstract #4216

Quantitative Magnetization Transfer MRI of the Knee Meniscus: Correlations with Biochemistry and Histology

Kirstin D Olsen1, Lumeng Cui1, Brennan E Berryman2, Ives R Levesque3, and Emily J McWalter2
1Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 2Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3Medical Physics, McGill University, Montreal, QC, Canada

The objective of this research was to determine if quantitative magnetization transfer (qMT) MRI can assess knee meniscus tissue health. Cadaver knee menisci underwent qMT assessment, biochemical content assessment, and histological scoring. Weak correlations were found between T1f and collagen content, T1f and histology score, and the histology scores and T2f and T2b. A moderate correlation was found between T2f and collagen content. qMT shows promise as a measure of meniscal tissue health but future studies with more severely damaged tissue are required to elucidate relationships between qMT and measures of meniscal content and health.

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