Abstract #4222

Vertebral bone marrow water T2 is sex-dependent and negatively correlated with age and the proton density fat fraction (PDFF)

Stefan Ruschke¹, Jan Syväri¹, Michael Dieckmeyer², Daniela Junker¹, Marcus R. Makowski¹, Thomas Baum², and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, ²Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany

Single-voxel multi-TE STEAM MRS data of the 4^th/5^th lumber vertebrae from 260 subjects (age: 0.7-77.7years) was retrospectively analyzed to investigate physiological variations of water T2 (T2W) in bone marrow. The data was fitted using a joint-series T2-constrained time domain-based water–fat signal model. Linear regression analysis indicated significant negative correlations for T2W vs. age and PDFF for both sexes, respectively. Females showed significant longer T2W values compared to males. Multiple linear regression revealed PDFF and sex as significant predictors of T2W. Underlying physiological variations of T2W are of relevance in the study of T2 variations and T2-weighted parameters.

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