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Abstract #4223

Quantitative Assessment of cartilage composition using MR T1ρ and T2 imaging 10 years Post ACL-Reconstruction

John P. Murray1,2,3, Richard Lartey1,3, Jeehun Kim1,3, Mei Li1,3, Sibaji Gaj1,3, Brendan Eck1,4, Donxing Xie1,3, Carl Winalski1,3,4, Faysal Altahawi3,4, Morgan H. Jones3,5, Bruce M Damon6, Laura J Huston7, Huyen T. Nguyen8, Michael V Knopp8, Kurt P. Spindler3,5, and Xiaojuan Li1,3,4
1Dept. of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, 2Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, 4Dept. of Diagnostic Radiology, Imaging Inst., Cleveland Clinic, Cleveland, OH, United States, 5Dept. of Orthopaedic Surgery, Orthopaedics and Rheumatology Inst., Cleveland, OH, United States, 6Dept. of Radiology, Vanderbilt University, Nashville, TN, United States, 7Dept. of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, TN, United States, 8Dept. of Radiology, Wright Ctr. Of Innovation in BioMed. Imaging, The Ohio State University, Columbus, OH, United States

This is a preliminary report for the MOON multivendor multisite 10 year follow up using quantitative MR imaging techniques for patients following ACL reconstruction. Imaging protocol was harmonized between sites and T1ρ and T2 imaging sequences that were cross-validated between sites and vendors were applied. Phantom data showed excellent intra-site repeatability and small inter-site variations. Significantly elevated cartilage T1ρ and T2 were observed in operated knees compared to contralateral knees. The preliminary results demonstrated feasibility of combining multi-site large cohort study with advanced quantitative MRI, with harmonized protocols and rigorous quality control for both data acquisition and processing.

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