Abstract #4223

Quantitative Assessment of cartilage composition using MR T1ρ and T2 imaging 10 years Post ACL-Reconstruction

John P. Murray^1,2,3, Richard Lartey^1,3, Jeehun Kim^1,3, Mei Li^1,3, Sibaji Gaj^1,3, Brendan Eck^1,4, Donxing Xie^1,3, Carl Winalski^1,3,4, Faysal Altahawi^3,4, Morgan H. Jones^3,5, Bruce M Damon⁶, Laura J Huston⁷, Huyen T. Nguyen⁸, Michael V Knopp⁸, Kurt P. Spindler^3,5, and Xiaojuan Li^1,3,4

¹Dept. of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ²Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ⁴Dept. of Diagnostic Radiology, Imaging Inst., Cleveland Clinic, Cleveland, OH, United States, ⁵Dept. of Orthopaedic Surgery, Orthopaedics and Rheumatology Inst., Cleveland, OH, United States, ⁶Dept. of Radiology, Vanderbilt University, Nashville, TN, United States, ⁷Dept. of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, TN, United States, ⁸Dept. of Radiology, Wright Ctr. Of Innovation in BioMed. Imaging, The Ohio State University, Columbus, OH, United States

This is a preliminary report for the MOON multivendor multisite 10 year follow up using quantitative MR imaging techniques for patients following ACL reconstruction. Imaging protocol was harmonized between sites and T1ρ and T2 imaging sequences that were cross-validated between sites and vendors were applied. Phantom data showed excellent intra-site repeatability and small inter-site variations. Significantly elevated cartilage T1ρ and T2 were observed in operated knees compared to contralateral knees. The preliminary results demonstrated feasibility of combining multi-site large cohort study with advanced quantitative MRI, with harmonized protocols and rigorous quality control for both data acquisition and processing.

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