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Abstract #4227

Three dimensional adiabatic T1ρ prepared ultrashort echo time Cones (3D UTE-Cones-AdiabT1ρ) imaging of knee joint degeneration

Mei Wu1,2, Yajun Ma1, Guanyuan Ning2, Saeed Jerban1, Yanping Xue1, Zhao Wei1, Eric Y Chang1,3, and Jiang Du1
1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

The three-dimensional adiabatic T1ρ prepared ultrashort echo time Cones (3D-UTE-Cones-AdiabT1ρ) sequence is a novel imaging technique that can provide magic angle-insensitive assessment of proteoglycan depletion in both short and long T2 tissues in the knee joint. We applied this sequence to healthy volunteers and patients with different degrees of OA for a systematic evaluation of its clinical performance. Results showed that the sequence could be used for quantitative evaluation of the knee cartilage degeneration, and that the 3D-UTE-Cones-AdiabT1ρ showed a significant positive relationship with WORMS and KL score,and significant difference in different extent and depth lesions of cartilage.

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