The three-dimensional adiabatic T1ρ prepared ultrashort echo time Cones (3D-UTE-Cones-AdiabT1ρ) sequence is a novel imaging technique that can provide magic angle-insensitive assessment of proteoglycan depletion in both short and long T2 tissues in the knee joint. We applied this sequence to healthy volunteers and patients with different degrees of OA for a systematic evaluation of its clinical performance. Results showed that the sequence could be used for quantitative evaluation of the knee cartilage degeneration, and that the 3D-UTE-Cones-AdiabT1ρ showed a significant positive relationship with WORMS and KL score，and significant difference in different extent and depth lesions of cartilage.
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