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Abstract #4233

Assessment of Osteoporosis in Human Lumbar Using 3D Adiabatic Inversion Recovery Prepared Ultrashort TE Cones Sequence

Jin Liu1, Yajun Ma2, Jianwei Liao1, Xiaojun Chen1, Wei Li1, Lin Yao1, Long Qian3, Jiang Du2, and Shaolin Li1
1Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China, 2Department of Radiology, University of California, San Diego, CA, United States, 3MR Research, GE Healthcare, Guangzhou, China

The 3D adiabatic inversion recovery prepared ultrashort TE cones (3D IR-UTE) sequence can image and quantify proton density assessment of short T2 water components in trabecular bone in vivo, and has the potential to diagnosis people with osteoporosis. The current study aims to prospective investigate the performance in diagnosing osteoporosis of IR-UTE sequence in human lumbar and to compare with quantitative computed tomography (QCT), dual-energy X-ray absorptiometry (DXA) and Fracture Risk Assessment Tool (FRAX) scores. It was concluded that IR-UTE was positively correlated to QCT and DXA, and was negatively correlated to FRAX scores.

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