Abstract #4238

Whole-body MRI reveals the burden of unsuspected synovitis in juvenile idiopathic arthritis

Varvara Choida^1,2, Timothy J.P. Bray^1,3, Alan Bainbridge⁴, Debajit Sen^2,5, Corinne Fisher^2,5, Maria Leandro^2,5, Coziana Ciurtin^2,5, and Margaret Hall-Craggs^1,3

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Centre for Adolescent Rheumatology Versus Arthritis at UCL UCLH and GOSH, University College London, London, United Kingdom, ³Radiology, University College London Hospital, London, United Kingdom, ⁴Medical Physics, University College London Hospitals, London, United Kingdom, ⁵Adolescent and young adult Rheumatology, University College London Hospital, London, United Kingdom

MRI is used for the detection of synovitis in juvenile idiopathic arthritis (JIA). We developed a whole-body MRI protocol, consisting of coronal, post-contrast mDixon images, which is fast and offers good coverage of peripheral joints and spine. A prospective study including 32 adolescent and young adult patients with JIA revealed that 43.8% of patients had synovitis in at least one joint on imaging that was not detectable clinically. The proportion of patients with subclinical synovitis was similar in clinically active and inactive patients. This could lead to identification of unsuspected inflammation in JIA patients with potential impact on their treatment.

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