Abstract #4239

Gadolinium-Free Assessment of Synovitis Using Diffusion Tensor Imaging

Halston J.C. Sandford¹, James W. MacKay², Lauren E. Watkins^1,3, Garry E. Gold^1,3,4, Feliks Kogan¹, and Valentina Mazzoli¹

¹Radiology, Stanford University, Stanford, CA, United States, ²University of East Anglia, Norwich, United Kingdom, ³Bioengineering, Stanford University, Stanford, CA, United States, ⁴Orthopaedic Surgery, Stanford University, Stanford, CA, United States

Synovitis is associated with osteophyte development and osteoarthritis progression. The intensity of synovitis can be quantified by K^trans, obtained from DCE-MRI using gadolinium-based contrast agent. Diffusion Tensor Imaging (DTI) has shown potential for detecting synovitis without administering contrast agent. This study assessed the potential of DTI to quantify synovitis by comparing DTI parameters (MD, FA) to K^trans within the whole synovium and adjacent to osteophytes. We found that FA negatively associates with K^trans in both regions, while MD has a positive correlation only within the whole synovium. DTI is a promising tool for assessing intensity of synovitis in osteoarthritic knees.

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