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Abstract #4239

Gadolinium-Free Assessment of Synovitis Using Diffusion Tensor Imaging

Halston J.C. Sandford1, James W. MacKay2, Lauren E. Watkins1,3, Garry E. Gold1,3,4, Feliks Kogan1, and Valentina Mazzoli1
1Radiology, Stanford University, Stanford, CA, United States, 2University of East Anglia, Norwich, United Kingdom, 3Bioengineering, Stanford University, Stanford, CA, United States, 4Orthopaedic Surgery, Stanford University, Stanford, CA, United States

Synovitis is associated with osteophyte development and osteoarthritis progression. The intensity of synovitis can be quantified by Ktrans, obtained from DCE-MRI using gadolinium-based contrast agent. Diffusion Tensor Imaging (DTI) has shown potential for detecting synovitis without administering contrast agent. This study assessed the potential of DTI to quantify synovitis by comparing DTI parameters (MD, FA) to Ktrans within the whole synovium and adjacent to osteophytes. We found that FA negatively associates with Ktrans in both regions, while MD has a positive correlation only within the whole synovium. DTI is a promising tool for assessing intensity of synovitis in osteoarthritic knees.

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