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Abstract #4256

Diffusion changes in prostate cancer patients undergoing radiation treatment on an MR-Linac system: Preliminary findings

Colleen Bailey1,2, Rachel W Chan1, Jay Detsky3,4, Danny Vesprini3,4, and Angus Z Lau1,2
1Odette Cancer Centre, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada

Eight prostate cancer patients undergoing radiation treatment were scanned on an MR-Linac with conventional ADC and high-b diffusion protocols at each of five treatment fractions. With the system’s weaker gradients and longer echo times, 6/8 patients had visible lesions at the maximum b-value of 2000 s/mm2. Fits to the VERDICT model demonstrated higher intracellular fraction in the lesion, inversely correlated with ADC. In three patients, ADC increased starting at the third treatment time point; a fourth patient exhibited a transient ADC increase. Future work will correlate these changes with biochemical recurrence to test their relevance as a biomarker.

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