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Abstract #4259

FMRI of Post High-Frequency Focused Ultrasound Ablation of ViM Shows Reduced Ipsilateral Thalamic and Cortical Motor Activation

Anna Crawford1, Mark Lowe1, Sean Nagel2, Daniel Lockwood1, Emmanuel Obusez1, Andre Machado2, and Stephen Jones1
1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 2Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States

High Intensity Focused Ultrasound (HIFU) in now entering clinical practice, for example to treat essential tremor (ET) by creating small lesions in the thalamus. Due to small size of treatment lesions, treatment success depends critically on targeting, which is classically done using measurements and landmarks. We explore an alternative method using functional imaging to guide targeting and assess efficacy, specifically using 7T task-related fMRI. We present preliminary data of the patterns of BOLD activation in a set of patients before and after HIFU.

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